I want to say that this is, of course, a severe trial for our country, a great trial indeed.
He is right that this is a severe trial for his country, but he is wrong in his belief that "other countries too have gone through such trials".
Irving was surprised and honored, writing, "It will be a severe trial to absent myself for a time from my dear little Sunnyside, but I shall return to it better enabled to carry it on comfortably".
His generosity to all literary ventures he regarded as worthy was remarkable, and his inability to reject appeals for help was a severe trial to his agent.
Many of his men blamed McCay for subjecting them to such a humiliating and severe trial.
Unanticipated risks emerging in early human gene therapy trials for severe combined immunodeficiency have led to patient deaths and reassessment of the hazards of viral vectors for human gene replacement, but far fewer investigations and regulatory adjustments.
Thus, many clinical trials for severe sepsis attempted to inhibit the action of PAF with a variety of PAF-R antagonists.
AFS is a consultant to both Eli Lilly and Astra Zeneca regarding the design of clinical trials for severe sepsis and septic shock.
Unfortunately, B-cell depletion does not lead to a positive outcome in clinical trials for severe SLE (Davies et al., 2013), and gave mixed results following repeated depletion (Ng et al., 2006).
The only possible way of avoiding this would be permanently (with an integrating vector) to transfect the stem cells of the airways; 18 such cells are difficult to reach, being buried beneath the surface and there are justifiable concerns over the use of integrating vectors, which have been shown to induce oncogenesis in gene therapy trials for severe immunodeficiencies.
In clinical gene therapy trials for X-linked severe combined immunodeficiency, the development of leukemia has come up as a severe adverse effect.
