More interestingly, there was a higher rate of severe phenotype by translation blocking morpholino than the splicing blocker.
Furthermore, a read-through mutation can cause more severe effects on translation when no additional stop codon follows.
Reduced levels of plastid 16S and/or 5S rRNAs in mutants of group I imply a severe drop in translation rates and consequently a general loss of transcripts synthesized by the PEP.
(The Russian word that Mr. Medvedev used for "harsher" can also be translated as "crueler" or "severer," and varying translations were published during the course of Thursday by English-language news media).
Ideally, RCTs would include more complex and severe patients to allow translation of results in daily practice.
Under conditions of severe stress or apoptosis, translation of HEL67 could be diminished and/or conformational changes within the ribosome could alter HEL67-rRNA interactions, hence allowing RNases to attack the non-translating ribosomes and to initiate rRNA breakdown.
Taken together, these results support a risk-benefit calculus that is in favour of combination therapy with memantine added to donepezil in moderate, as well as moderate to severe AD, and imply translation of clinically meaningful benefits to patients, caregivers, and society.
By having relatively severe effects on the translation of mRNAs encoding products involved in processes such as protein turnover, nutrient storage, or cell cycle progression, TOR might alter the balance between rates of cell growth and division, and thus affect cell size.
L and BP cells are smaller, have lower protein content (Figure 2A,B), synthesize less protein and show a severe reduction in cap-dependent translation and in the levels of the protein factors executing this type of translation (Figure 3A,B).
These codons, termed as "slow" codons, become bottlenecks in the mRNA translation, and have severe effects on the steady state solutions [ 57- 60].
