Skull and Crossbones: Substances, such as poisons and highly concentrated acids, which have an immediate and severe toxic effect (acute toxicity).
The more severe toxic effects include psychosis or adverse psychiatric events, renal toxicity, respiratory failure, hyperthermia, serotonin syndrome, rhabdomyolysis and seizure.
Although complete and partial regressions of several cancers such as lymphoma, melanoma and acute lymphocytic leukaemia were noted, severe toxic effects were observed in those early clinical trials.
The levels found "greatly exceed concentrations at which severe toxic effects are known to occur," the scientists found.
Note: All such calculations are very rough estimates, and severe toxic reactions can occur at much lower doses depending on the health of the individual.
cis-Pt(NH3 2Cl2 (cisplatin) is an antitumor drug with many severe toxic side effects including enzymatic changes associated with its mechanism of action.
Taken together, these data indicate that phosphaplatins have the potential to treat resistant ovarian cancers, both acquired and de novo, without exhibiting severe toxic effects.
Some nootropic drugs like piracetam, aniracetam and cholinesterase inhibitors such as Donepezil® have found to exhibit severe toxic effects in elderly.
An important drawback of these chemotherapeutics is the lack of selectivity for tumour cells, usually resulting in severe toxic side effects.
Inhibition of CYP 3A4 catalytic activity is a principal mechanism for in vivo drug drug interactions, sometimes leading to severe toxic effects.
The optimal dose is typically the Maximum Tolerated Dose (MTD) defined by the occurrence of severe toxic side effects during the first course of treatment.
