Despite these severe tolerances on damage, TDSs are designed with relatively large ballistic damage tolerance.
Severe tolerances on mechanical components have created increasingly stringent demands on the quality of new mechanical designs.
We found that down-regulation of several candidate genes including Best1, broad, CG7102, dunce, lin19-like and sec6 conferred severe hypoxia tolerance in Drosophila.
Even less severe glucose tolerance abnormalities such as IGT are associated with lung function decline (12, 17).
There were no drug-related immune responses or moderate or severe local tolerance reactions observed in this trial.
Moderate or severe local tolerance reactions up to 24 h after any injection of corifollitropin alfa, OHSS, ectopic pregnancy and miscarriage were always considered at least an AE.
Our work demonstrated a novel involvement of HaHSFA4a in seed longevity and severe stress tolerance, as well as the strict dependency on HaHSFA9 (or similar tobacco HSF) of the functional effects of HaHSFA4a.
More severe glucose tolerance abnormalities develop in those who either have worse inflammation and thus greater insulin resistance, or who have intrinsic β-cell dysfunction related to type 2 diabetes associated genetic variations.
In view of the very low titre and the absence of neutralizing activity, of moderate or severe local tolerance reactions and of any AEs, the test result was judged as not clinically relevant.
Other strengths are the calculation of person-years at risk and the use of interval-censoring, which takes into account the fact that conversion to a more severe glucose tolerance state occurs before the time of the examination.
