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We observed nine rare non-synonymous SNPs, which were only present in subjects with severe white matter lesions.
Except for two of these SNPs (V1183M and V1952M), they were exclusively or mainly detected in subjects with severe white matter lesions.
Sorting Intolerant From Tolerant, PolyPhen2 analyses and protein structure simulation consistently predicted six of the non-synonymous single nucleotide polymorphisms (H170R, P496L, V1183M, L1518M, D1823N and V1952M) to be functional, with four being exclusively or mainly detected in subjects with severe white matter lesions.
"It's too serious a subject matter.
Others have subject-matter expertise.
Subject-matter experts were given double weight.
Eighty-eight per cent of subjects had mild white matter involvement (modified Scheltens score 0 10), 12% showed moderate involvement (scores 11 20) and none showed severe white matter involvement.
Simon's show at Callicoon is reminiscent of the shows at Orchard 47, combining socially conscientious subject matter with a severe academic aesthetic.
Is the subject matter too hard?
Residents with severe dementia were excluded from the study because of the complex subject matter of the interviews.
For subject matter, he uses the life around him, including a severe drought that affected his community and the high number of HIV-positive residents of his village.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com