Sentence examples for severe structural and functional from inspiring English sources

Peripheral nerve injury during the critical period of development imparts severe structural and functional consequences on the muscles of the growing animal.

In rodents, double knock-out of APP and APLP-1 induces severe structural and functional synaptic deficits [ 66], pointing to the crucial role of APP family members in synapse development and maintenance.

Adult flies fed an HSD develop severe structural and functional alterations of the heart (Table 2), as well as essentially all the phenotypes observed in the larval model (Musselman et al., 2011; Na et al., 2013).

In contrast, incubation of either of the two cell lines with 500 μg/mL of the other Rhododendron leaf extracts resulted in severe structural and functional alterations often associated with signs of apoptosis.

Mild deficits in synaptic plasticity in neurons of the hippocampus have been observed, 58 but only the complete knockout of four related proteoglycans resulted in severe structural and functional abnormalities.

The severe structural and functional abnormalities of the central nervous system (CNS) seen in patients with peroxisome biogenesis disorders (PBDs) (Evrard et al. 1978; Powers et al. 1985) (Table  1) demonstrate the important role of peroxisomes in normal development and function of the brain.

We used antisense morpholino technology to generate zebrafish embryos with dominant-negative transcripts of col6a1 that result in severe morphologic, structural and functional changes.

In conclusion, our data demonstrate an integrated down-regulation of the photosynthetic process to maintain intrinsic balance between electron transfer reactions and reductive carbon metabolism without severe damage to PSII structural and functional integrity.

The breakdown of phospholipids causes severe changes in the structural and functional integrity of the plasmatic membrane with a consequent influx of calcium ions [ 62], release of calcium-dependent proteases [ 63], activation of endogenous PLA2s [ 64], and mitochondrial collapse [ 65].

The hub vulnerability hypothesis would predict that an acute severe global insult would cause greater structural and functional damage to hub regions than to non-hubs.

Quantitative functional outcome measures were incorporated to facilitate assessment of new technologies to promote structural and functional limb salvage following severe extremity trauma.