Diffuse intrinsic pontine glioma (DIPG) is the most severe paediatric solid tumour, with no significant therapeutic progress made in the past 50 years.
Patients with severe immunosuppression (solid organ transplantation or steroid therapy ≤ 20 mg/day for more than two weeks), witnessed aspiration, or in whom the pneumonia was an expected terminal event resulting from metastatic cancer were excluded.
Patients with aspiration, severe immunosuppression (solid organ transplantation, steroid therapy ≥10 mg/d for more than 2 weeks, known Human Immunodeficiency Virus, or Acquired Immunodeficiency Syndrome defining criteria), underlying active malignancy, or who had a Do-Not Resuscitate order (DNR) were also excluded.
Ibuprofen powders, considered as model Geldart group C powders with Sauter mean diameters of 41 μm (coarse) and 22 μm (micronized), could not be fluidized due to severe agglomeration, solid-bridging, and poor flowability.
d Development of NRBC counts over the course of time in severe ARDS (red solid line; red dashed line indicates trend) and moderate ARDS (black solid line; black dashed line indicates trend) depicted as relative effect over time.
Surface subsidence and severe damage by solid wastes are major environmental disasters in mining.
Spherical aberrations of thermal lens of the active media are severe when the solid state lasers are strongly pumped.
The objective is to evaluate the outcome and prognostic factors in a group of patients with severe sepsis and solid tumours.
After excluding patients who were treated with HSCT for metabolic disorders, severe combined immunodeficiency, or solid cancers (n=230), who had solid cancer before HSCT (n=112), who had <1 year of follow-up (n=1122), and who developed secondary solid cancer within 1 year after HSCT (n=6), a total of 2544 patients met eligibility criteria and were enrolled in the study (Supplementary Figure 1).
The high acuity of illness, as well as the presence of severe comorbidities, such as solid and hematologic oncologic conditions (7 patients), chronic renal insufficiency (6 patients), and cirrhosis of the liver (4 patients), likely contributed to the poor outcomes in the noninfluenza group.
