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Also, FD patients exhibit severe skeleton problems that worsen with age.
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Among these sites, bone is the most challenging organ for therapeutic intervention as bone metastasis can cause severe skeleton-related diseases such as bone pain, hypercalcemia, fractures and nerve compression syndromes (Saad et al, 2006; Sturge et al, 2011).
Severe damage and mixed, tiny pieces originating from several skeletons may render morphological classification virtually impossible.
For AG93 the trabecular tissue is on average 8 times higher in Fe concentrations – indicating that groundwater deposition of Fe over the years has been much more severe for this skeleton.
Other exclusion criteria were radiation therapy within 4 weeks from treatment initiation, irradiation of more than 25% of the bone marrow-bearing skeleton, severe infection or malnutrition.
Severe scoliosis in the skeleton found under a Leicester car park less than two years ago – and DNA matches with a distant relative of the Plantagenet king – helped to confirm "beyond reasonable doubt" the identity of the remains.
Morquio syndrome, also called mucopolysaccharidosis IV, rare hereditary disorder of intracartilaginous bone development that results in severe malformation of the skeleton (particularly the spine and long bones) and dwarfing.
In the mouse, it was shown that Dmrt2 is required for somite differentiation with severe implications on axial skeleton development [24].
The indications for resection were location in the axial skeleton or severe joint destruction.
The skeleton also showed severe scoliosis - a curvature of the spine.
This is evident especially in children and young adults with a flexible skeleton in whom severe visceral traumas may occur despite there being no fractures.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com