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These studies begin to define how acinar cell differentiation programs may act as an important defense in a progressively severe sequence of events: loss of the mature acinar phenotype, PanIN initiation, and formation of PDAC.
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These sorts of vagueness and uncertainty are due to lack of knowledge for the severe accident sequences of interest.
Severity can be minimized by using the least severe procedures and sequence of procedures, and by setting humane endpoints, and, in a sequence of experiments, by setting review points and starting with lower severity studies.
In this paper, we demonstrate molecular (Figure 7) and functional changes of the cerebrum of late preterm lambs in a unique experimental standardized sequence of severe asphyxia due to complete umbilical cord occlusion in utero, fetal cardiac arrest, emergency cesarean section, postnatal resuscitation of the fetus, and intensive care for the first 8 h after birth.
What it shows, in essence, is that the sequence of severe obesity followed by fairly drastic weight loss activates the body's primitive defenses against starvation, which is, in effect, what it is experiencing.
"So far, the vast majority of children born with HIV/AIDS in Mozambique have a very short life, which for most of the time is characterized by a sequence of severe diseases.
For example, rare protein-coding mutations of the FOXP2 transcription factor cause severe problems with sequencing of speech sounds, while common genetic risk variants of small effect size in genes like CNTNAP2, ATP2C2 and CMIP are associated with typical forms of language impairment.
This article describes a sequence of treatments for a severe mandibular defect.
For the Chinese 600MWe pressurized water reactor (PWR) with a large-dry containment, large break loss-of-coolant accident (LB-LOCA) is screened out as the reference severe accident sequence, considering the nature of hydrogen generation and the probabilistic safety assessment (PSA) result on accident sequences.
To overcome this severe mathematical difficulty, we restrict ourselves to a sequence of closed subspaces (H_^{1}) and (H_^{2}).
These severe limitations of sequence trees emphatically do not mean that they are worthless.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com