Sentence examples for severe phenotypic changes from inspiring English sources

Hepatocytes transfected with HNF1α siRNA underwent severe phenotypic changes with loss of cell-cell contacts and development of migration structures.

Phytoplasma are insect-transmitted bacterial pathogens that cause severe phenotypic changes in the host morphology to enhance the fitness of their insect vectors.

Strong reduction of TS activity and/or significant accumulation of methionine, however, were accompanied by severe phenotypic changes and acute reduction in tuber yield [ 4].

Since creA/cre1-knock out mutants display severe phenotypic changes such as reduced growth, abnormal hyphal morphology and sporulation [ 17, 18], such studies are only possible under carefully controlled conditions.

After severe sepsis, phenotypic changes modulate DC functions and may contribute to sepsis-induced immunosuppression.

Imprinting disorders are caused by loss or gain of parental DNA methylation at imprinted loci which results in aberrant gene expression during development and thereby leads to severe, irreversible phenotypic changes [ 119, 120].

Several significant phenotypic changes were observed in the AF flies.

As these phenotypic changes became more severe, fewer cells appeared to be in mitosis.