Sentence examples for severe phenotype of from inspiring English sources

Inoue et al. observed that DAT-Atg7−/− exhibits an even more severe phenotype of age-dependent neurodegeneration than CamKII-Atg7−/− mice (Inoue et al., 2012a).

The results of our survey indicated that the smoking status was associated with a more severe phenotype of CH than that of patients who had never smoked.

For NPHP3, the phenotypic variability can be explained by the type of mutation with biallelic missense mutations resulting in the less severe phenotype of isolated nephronophthisis and two truncating mutations resulting in a Meckel-Gruber phenotype [18].

Thus, a higher incidence of the genetic aberration in affected organs as lung and diaphragm cannot explain the severe phenotype of this complex CDH patient.

The current work provides an explanation for the severe phenotype of MPS IIIC patients carrying missense mutations in the HGSNAT gene.

Previously we reported that ssadh mutants accumulate high levels of ROIs, which is associated with the severe phenotype of these mutants [26].

Alternatively, the more severe phenotype of icl-TetON could have resulted from a competition with other strains in the multi-strain infection.

To elucidate the role of succinic semialdehyde (SSA), γ-hydroxybutyrate (GHB) and GABA in the accumulation of ROIs, we combined two genetic approaches to suppress the severe phenotype of ssadh mutants.

The much less severe phenotype of the DIO mouse compared to the genetically-induced obese animals may account for the absence of increased ceramide synthesis and accumulation, at least in the liver.

The implication of p63 in pluristratified epithelia morphogenesis/maintenance in mice was revealed by the severe phenotype of p63-deficient mice, born with a defect in all pluristratified epithelia [2], [3].

Their co-overexpression, however, resulted in the severe phenotype of isotropic growth.