This indicated severe replication pausing or stalling and caused mtDNA depletion.
With the γ-OH-PdG-adducted templates, the extent of the blockage to DNA synthesis was more severe, with a major pause site detected one nucleotide prior to the lesion and another pause site opposite the lesion.
Pohl M, Rückreim S, Mehrholz J, Ritschel C, Strik H, Pause MR. Effectiveness of serial casting in patients with severe cerebral spasticity: a comparison study.
But drink it slowly, taking pauses in between, otherwise it'll make coughing severe.
You can hear his voice cracking up; the pauses before several words betray the feelings of a man who is under severe strain.
Cardiac conduction was investigated: Holter-ECG confirmed severe bradycardia with minimal nocturnal heart rate of 28 bpm; any significant pause was recorded.
Pohl M, Rückriem S, Strik H, Hörtinger B, Meiβner D, Mehrholz J, Pause M. Treatment of pressure ulcers by serial casting in patients with severe spasticity of cerebral origin.
In spectacles and black vestments, he's a severe type who demands of even fast-talking Americans total comfort with long pauses.
Extended pauses carry great weight here, and the play-within-a-play scene is severe and frightening.
The peloton paused while Froome was treated from the team doctor's car, TV pictures showing severe grazing to his hip.
Severe complications under chemotherapy required hospitalization for 5.3 weeks (37 days), during which complete chemotherapy was paused.
