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"It took 17 Dumpsters to get the stuff out, and we're still clearing out the basement," Ms. Malek said, adding that the entire house would be gutted, and the severe overgrowth of wild trees on the property would have to be addressed.
Since we were interested in analyzing the effects of ph mutations specifically on epithelial integrity, we continued the analysis using heat shock conditions that allow uncoupling of the epithelial instability and more severe overgrowth phenotypes.
Therefore our experimental conditions allow us to uncouple cell adhesion and overgrowth due to ph mutations and to study cell adhesion and epithelial instability independently of the severe overgrowth phenotypes.
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The cyclic polyaniline nanostructures were formed by severe secondary overgrowth through the electrostatic interaction between aniline/oligoaniline and polyacrylic acid chains.
Conversely, Fxr KO mice displayed more severe bacteria overgrowth and epithelial barrier deterioration.
An interesting finding was the observation that small intestinal bacterial overgrowth predicted severe hepatic steatosis [ 47].
Therefore, it is the loss of HSCs in the mutant animals that ultimately leads to lymph gland overgrowth and severe change in hemocyte homeostasis.
However, C. albicans as well as other Candida species (e.g., C. parapsilosis or C. krusei) may lead to morbidity and mortality in immunocompromised patients as a consequence of fungal overgrowth and severe cutaneous or systemic infections.
Homozygous mutants die at embryonic day 16.5, and their phenotype includes severe craniofacial malformations, brain overgrowth, persistence of the interdigital webs, and dramatic alterations of the lens and retina.
Hypertrophy of soft tissues and bone is more frequently for the lower limbs but any part of the body can be affected with variable extension, which can even be limited to only the fingers or toes or may be severe with massive limb overgrowth [ 87, 88].
One of the most severe forms produces polyps, overgrowths of unhealthy sinus tissue that can block the nose and sinus passages and make breathing through the nose difficult or impossible.
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