As more information becomes available related to the response of symptoms, lung function, and exacerbations to good maintenance bronchodilator therapy in COPD patients with less severe disease, opinion is moving towards using effective bronchodilation in the earlier stages of COPD [ 18, 26].
One might expect someone of such severe aesthetic opinions to be dour and humorless, but in fact Safdie is exceptionally charming.
While some of the participants from the severe group gave opinions regarding difficulty, most had trouble with verbatim responses to the Likert question.
We shall not, therefore, be suspected of forming, upon any of his acts, an opinion more severe than they deserve.
Hypertriglyceridemia may have contributed to the clinical signs, but was in our opinion not severe enough to explain all the clinical findings.
This was published after completion of our study; thus, we used as our primary case-definition, acute renal failure severe enough, in the opinion of the treating intensivist, to warrant the initiation of RRT.
Because of the poor response rate and the presence of severe toxicity, in our opinion further clinical trials in head and neck cancer should be attempted only after a better definition in preclinical studies of interactions among 5-fluorouracil, cisplatin and interferon.
The severity of events (mild, moderate, or severe) and the investigator's opinion about whether the event was related to study drug were recorded.
The severity of events (mild, moderate, or severe) and the investigator's opinion concerning whether the event was related to study drug were noted.
Though he of course wildly exaggerated any motive on the part of his detractors, there is a sliver of medical credence to Kitaj's belief – recent medical opinion does acknowledge severe stress, and resultant raised blood pressure, as an exacerbating factor in aneurysms of the type that Fisher suffered.
