Sentence examples for severe off from inspiring English sources

Of these, two patients could not perform the tasks due to severe OFF medication akinesia, a deficit that appears unresponsive to pedunculopontine nucleus stimulation (Moro et al., 2010).

It is a fast-acting, short-duration treatment used for advanced PD as a rescue therapy for patients with severe "off " periods and has been shown to reduce daily "off" time by an average of 2 hours.

Ford says it is convinced that most Explorer buyers don't care about severe off-road driving and that its own version of Selec-Terrain (called Terrain Management) will handle most chores.

Whenever the driver selects the transmission's most severe off-road choice -- the "4 LO Locked" position, the ratio of gas pedal motion to movement at the engine throttle is dialed back electronically, making it less hair-trigger and easier for the driver to control.

Interestingly, spacers ≤ 20 nt led to unsuccessful transformation consistently, likely due to severe off-target effects; while a spacer of 30 38 nt is most appropriate to ensure successful transformation and high genome editing efficiency.

However, the application of epigenetic drugs other than miRNA-targeting drugs in non-malignant diseases still has to overcome major hurdles because of potential severe off-target effects.

Cisplatin was the first Pt-based drug used in cancer therapy but, unfortunately, it exhibits severe off-target effects and cancers often acquire resistance to the drug (Lebwohl and Canetta 1998; Wang and Lippard 2005).

We crept into different universities, with severe tickings off and orders to improve our attitude.

Survival involves "an extreme hardening of normal human softness, a severe cutting off from emotions and sensitivity".

Bash, LaBute's 1999 triptych of modern Greek tragedies, got him a severe ticking off from the Mormon Church, to which he and the play's murderous characters belonged.

A chart showing fluctuations of the G.D.P. over the past few years indicates a modest recovery beginning in the middle of 2009, just as the stimulus dispersals were kicking in; the recovery continuing at a decent clip for more than a year; and a severe tapering off toward the end of 2010, by which time most of the stimulus money had been spent.