Sentence examples for severe nail from inspiring English sources

Using whole exome sequencing, we identified in a child with congenital exfoliative erythroderma, hypotrichosis, severe nail dystrophy and failure to thrive, two heterozygous mutations in ABCA12 (c.2956C>T, p.R986W; c.5778+2T>C, p. G1900Mfs*16), a gene known to be associated with two forms of ichthyosis, autosomal recessive congenital ichthyosis, and harlequin ichthyosis.

12 The hallmark of PC is severe nail thickening due to massive nail hyperkeratosis.

Special clinical situations may change mild psoriasis to moderate to severe including involvement of visible areas or severe nail involvement.

A further, rare disease recently found to be related to a distinct mutation in the type II hair keratin K85 is ectodermal dysplasia of hair and nail type, characterized by total alopecia and severe nail dystrophy (Naeem et al. 2006).

Toxicity-related withdrawals were severe nail disorders (n=3), dyspnoea (n=2), cutaneous toxicity (n=2), asthenia (n=1), haematological toxicity (n=1), oedema (n=1), pain and poor general well-being (n=1), pulmonary embolism (n=1) and femur fracture (n=1).

Be aware that psychiatrists recently reclassified severe nail biting to be a type of pathological grooming.

Remember that severe nail-biting can also cause health problems.

Because the patient displayed an atypical phenotype, including severe hair and nail manifestations, we scrutinized the exome sequencing data for additional potentially deleterious genetic variations in genes of relevance to the cornification process.

Therefore, some studies make a distinction between mild forms and severe forms of nail biting [ 7].

We believe that severe skin and nail infections with Staphylococcus species are unique side effects resulting from the addition of pertuzumab to trastuzumab-based chemotherapy.

In our series, folliculitis was observed early, however, the more severe infections and nail infections developed after cycles 3 and 4. In total, the toxicity data for the combination of pertuzumab and trastuzumab are based on 846 patients, 556 of whom received six cycles, 215 four cycles, and 75 three cycles.