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In some patients with sCAD the reticular dermis has a similar, although less severe, morphology to heterozygous relatives of PXE patients with fragmented, cribriform, and mineralized collagen bundles and EFs [ 139].
Consistent with the more severe morphology observed in 35S HvCesA4 dwarf plants (i.e. collapsed xylem), their xylem cell walls were thinner overall, had irregular edges and were occasionally interrupted by apparent gaps in the middle lamella layer.
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tc243 has severe morphological defects in leaf, plant height, inflorescence and flower morphology.
Moreover, even the ESL G11 cell line with the most severe differentiation morphology failed to generate obvious EB by day five, suggesting severely compromised differentiation capability (Figure 5B h).
Finally, we found that overexpression of both clathrin heavy chain and epsin suppress nearly completely the lethality and severe eye morphology defects of auxilin mutants.
The outcome of a sample was defined by the most severe SNOMED morphology code.
Loss of Nesprin-2 has been shown to cause severe nuclear morphology defects in LMNA S143F progeria cells (Kandert et al., 2007) and Nesprin-2 knockout mice show an increase in nuclear volume (Lüke et al., 2008) suggesting that loss of Nesprin-2 Giant from the NE results in nuclear morphology defects.
In agreement with the cell-free data, RNAi-mediated depletion of Nup53 in HeLa cells results in severe nuclear morphology defects and reduced levels of Nup93, Nup205 and Nup155 at the nuclear rim, suggestive of defects in NPC assembly (Hawryluk-Gara et al, 2005).
Types 1 and 2 represent normal and mild inflammation morphologies, and types 3 5 represent moderate to severe inflammation morphologies [ 9, 13].
Primary keratinocytes isolated from knockout mice and subsequently cultured had altered morphology, severe adhesion and growth defects and underwent apoptosis.
Further, by staining with FM4-64, severe defects in morphology were observed in the Δga5dh cells.
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