Sentence examples for severe morphological and from inspiring English sources

Indeed when Pmp23 is absent or is mutated on one of the putative catalytic residues E61 or D68, S. pneumoniae cells are larger and longer, and a portion of them displays severe morphological and division defects.

Opposed to our initial hypothesis, the severe morphological and presumably functional barrier alterations associated with AD [13 16, 18, 31] did not increase the penetration of CMS past the stratum corneum.

All these observations indicate severe morphological and structural alterations occurring in the diabetic heart (19, 23).

Loss of neurons through these apoptotic deaths results in severe morphological and functional deficits, which manifest with progressive memory and cognitive decline.

We wished to uncouple the role of periaxin in regulating Schwann cell elongation from the severe morphological and functional consequences of its complete absence.

An important observation of these studies is that dasatinib treatment induced severe morphological and functional changes in the sensitive MDA-MB-231 cells.

Acute co-ablation of C/EBPα and C/EBPβ in sebaceous glands resulted in severe morphological defects, and sebocyte differentiation was blocked as determined by lack of sebum production and reduced expression of stearoyl-CoA desaturase (SCD3) and melanocortin 5 receptor (MC5R), two markers of terminal sebocyte differentiation.

Inactivation of condensin subunits by mutation or depletion results in severe morphological aberrations and mechanical sensitivity of metaphase chromosomes, and subsequently to defects in their segregation during anaphase (Hirano and Mitchison, 1994; Ono et al., 2003; Gerlich et al., 2006).

While the expansion of isolated cells in the static environment of a culture dish is easy to perform, developing tissues frequently illustrate severe morphological, physiological and biochemical alterations caused by dedifferentiation especially in combination with innovative biomaterials[1 8].

Expression of UAS-C3GCA at 18°C allowed development of larvae displaying severe morphological defects and disruption of actin organization in somatic muscle (Figure 6C).

Our results showed that even in the absence of these p53 regulatory RPs, the embryos displayed severe morphological deformities and a high level of apoptosis, indicating an activated p53 response (Figure S5).