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A second example is that of Yervoy® (ipilimumab), a product that was approved in the USA for the treatment of late-stage melanoma with a risk-minimization communication program designed to address severe autoimmune reactions [ 52].
As we discussed previously [ 5], this analysis demonstrates a surprising degree of statistical heterogeneity, which remains despite minimal methodologic differences between the two trials and further minimization of clinical heterogeneity by selecting a more uniform subgroup of patients with severe sepsis and a high risk for death.
Minimization, it would seem, would be minimal.
However, the theory of Minimization of Metabolic Adjustment (MOMA) suggested that when a severe perturbation occurred, the system adjusted itself to some extent towards a state that was close to normal [ 16].
The systems were first minimized through 500 steps of steepest descent minimization and a following 500 steps of conjugate gradient minimization.
The solution method incorporates the Tikhonov regularization for tackling the severe ill-posedness and the conjugate gradient (CG) method for solving the resulting minimization problems.
Achieving tolerance or drug minimization after transplantation and thus preventing permanent immunosuppression with all the known severe side effects is the most important goal in transplantation medicine.
Caregivers' interviews revealed substantial strain from caregiving responsibilities as well as frequent symptom minimization by patients.The diverse and unique experiences of acute respiratory distress syndrome survivors reflect the global impact of severe critical illness.
Minimization: does a principle of minimization apply?
"There's no time for harm minimization".
Empirical risk minimization.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com