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This reagent produced more severe migration phenotypes than our newly developed CRISPR/Cas9 assay, which nevertheless strongly inhibits Foxf expression (Gandhi et al., 201736 and Fig. 1b).
Strikingly, the majority of cells transfected with either RHEBp.P37L or RHEBp.S68P remained in the subplate (SP), indicating more severe migration deficits compared to RHEB-WT overexpression (Fig. 4a).
Nevertheless, due to the application of perfluorinated membranes, VRFBs are plagued by not only the severe migration issue of vanadium ions, but also their high cost.
Donald Trump has warned there are "many options", including a military one, to deal with Venezuela's collapse, responsible for the most severe migration crisis in modern Latin American history.
Harold Trinkunas, a Stanford University Latin America expert, said Venezuela's problems, which has caused the most severe migration crisis in modern Latin American history, had become "a really powerful tool for Bolsonaro to attack the PT and Haddad".
The RTM result of incomplete data shown in Fig. 12a, b contains more severe migration artifacts compared with the RTM result of the complete data.
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Beltran-Valero de Bernabe, D. et al. Mutations in the O-mannosyltransferase gene POMT1 give rise to the severe neuronal migration disorder Walker Warburg syndrome.
In two-dimensional experiments with unsaturated porous medium contaminated with nonaqueous phase liquids, it was demonstrated how injection of pure steam lead to severe downward migration.
Further dissecting the pathomechanism(s) underlying RHEB-associated ID, we showed severe neuronal migration defects in mouse embryos electroporated with mutant RHEB and an increased incidence of epileptogenic activity postnatally.
Severe river migration conditions can greatly exacerbate this mortality (Macdonald 2000; Macdonald et al. 2000; Farrell et al. 2008).
The impact of lower population size will be particularly severe if migration among populations is also reduced as a result of blockages.
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