Of note, despite their severe wing margin loss, Notch +/− ; Ser gt-wt /Ser gt-wt animals only showed a mild enhancement of the wing vein thickening compared to Notch +/− flies.
Oregon blamed the losses on an "unprecedented increase in timber prices in the first half of 2010, which resulted in a severe erosion of margin".
Where neutrophil depletion was attempted, the coinfection was so severe that no margin to observe further aggravation was left 35.
The three methods investigated in this study show comparable feasibility, clinical utility, lack of severe complications and margin of patient safety under the conditions of a secondary academic teaching hospital.
While this pattern is familiar, the company said the sheer magnitude of its product-line overhaul made the decline in gross margin more severe.
The current crisis is by considerable margin more severe than the historical mean, so it may be that wringing excessive debt off the balance sheets of the world's rich countries—household debt, corporate debt, commercial real-estate loans (an unfolding bust now in the U.S). and government debt could take a decade or even longer.
The current crisis is by considerable margin more severe than the historical mean, so it may be that wringing excessive debt off the balance sheets of the world's rich countries — household debt, corporate debt, commercial real-estate loans (an unfolding bust now in the U.S). and government debt — could take a decade or even longer.
A histologically-confirmed positive margin for severe dysplasia or greater histological change, either at the intraoperative or paraffin sample assessment, will count as failure of the 'first pass' margin (surgical failure).
However, one can assume that, in patients with moderate to severe disease expression, the margin by which one can afford inappropriate therapy is much smaller than in patients presenting with mild disease.
