Sentence examples for severe loss of function from inspiring English sources

In contrast to Nosp, which is a facultative symbiont, NoAz spends its entire life cycle in a perpetual plant interaction and has suffered severe loss of function with a massive number of pseudogenes mainly in the functional categories related to replication, secondary metabolite biosynthesis, and signal transduction [ 8].

Following tendon injury, severe loss of function often occurs either as a result of obliteration of the synovial canal with fibrous scar tissue or from rupture of the repaired tendon.

The sctt maternal-/zygotic- germ cell phenotype suggested that the molecular defect causing this phenotype represents a severe loss of function.

The severe loss of function phenotype seen in tre1sctt mutants offered a unique opportunity to perform a detailed structure-function analysis of this region of the Tre1 GPCR.

We conclude that the BcorNeo allele is a severe loss of function allele but because we did detect some correctly spliced transcript it may not be a null allele.

In summary, both the BcorNeo and BcorGt alleles represent severe loss of function mutations and result in kinked and shortened tails and a coat color bias in chimeric animals.

Genes whose severe loss-of-function is lethal or highly pleiotropic cannot be functionally dissected with such mutants.

Clinical severity might depend on the type of mutations present, such that severe loss-of-function mutations (e.g., truncating alleles) lead to severe disease, while more moderate mutations with residual protein function (e.g., hypomorphic missense changes) may give rise to milder phenotypes with later disease onset and possibly also slower progression.

Here, we describe severe loss-of-function mutations in MC2R in seven children from three kindred, several of whom had evidence of disturbed renin-sodium homeostasis and were receiving mineralocorticoid replacement.

We conclude that Asxl2− is a severe loss-of-function allele.

Notably, dozens of other severe loss-of-function mutations in SCN5A are known to cause BrS, CCD, or both [28].