Sentence examples for severe limitations including from inspiring English sources

However, such number has severe limitations including the impossibility of excluding the outliers.

However, this radioligand is recognized to have severe limitations, including low sensitivity and poor amenability to quantification.

Many protocols suffer from severe limitations including only partial protection of the RNA integrity and/or loss of small sized molecules.

Previous methodologies for studying mitochondrial aging have severe limitations including a lack of spatial resolution and live-cell applicability. 2 We present a novel approach based on a time-sensitive fluorescent protein that is targeted to the mitochondrial matrix (MitoTimer).

While randomized controlled trials (RCTs) can and do make valuable contributions, they also have severe limitations, including in answering the basic question of "Does it work?" and, even more so, in steering how to proceed with complex public health programming at scale.

Even though the odds of lung disease were higher among the childhood pneumonia case-patients compared with controls (odds ratio 2.93, 95% CI 0.69 12.48), the study had severe limitations, including small sample size and potential bias (only 68 of 190 possible cases were traced).

Pentostam and Glucantime are first-line drugs for both VL and CL; however, they present several limitations, including severe side effects, the need for daily parenteral administration, and the development of drug resistance.

Although hospital-based data suffer several limitations, including a bias to more severe disease, the severe end of the disease spectrum is where the biggest health impact will be made by both vaccines and therapeutics.

However, these studies had several limitations, including retrospective design [ 17], and inconsistent definitions of severity ranging from severe pancreatitis based on the Atlanta criteria to mortality [ 17, 18].

In most clinical trials performed in this area, often burdened by severe methodologic limitations including excessive clinical heterogeneity, investigators use different definitions of SE (and its stages), adopt inappropriate comparators, or use unclear methods of data presentation [ 35– 37], so that reaching definite evidence is an extremely challenging task.

In the present study, disability was defined based on six ADL functions and mobility limitations, including moderate and severe disability levels.