Sentence examples for severe lethality from inspiring English sources
Muscle-specific RNAi against dSmyd4 resulted in depletion of the protein and lead to severe lethality.
Indeed, while the inactivation of tiar and tia-1 genes both leads to relatively severe lethality, tiar−/− survivors only suffer from impaired gametogenesis and infertility due to disorders in the development process of primordial germ cells [1], [11].
This adverse effect on the skin occurred early (neonatal stage) and was severe (lethality).
Afterwards, although 5-LO−/− mice presented less severe lethality when compared to WT mice, progressive lethality did occur.
When exposed to the DNA-damaging agents HU, MMS, or CPT at concentrations that cause severe lethality in an rfa1 -t11 mutant, both single mutants in either phospho-mutant form did not display damage sensitivity.
Nav1.1 deletion using Emx1-Cre does not cause any noticeable abnormalities in mice; however, the severe lethality observed with VGAT-Cre-driven Nav1.1 deletion is rescued by additional Nav1.1 deletion using Emx1-Cre.
This result is consistent with another dominant allele of TBA-1, or346, that disrupts mitotic spindle positioning and causes severe embryonic lethality [37].
However, the in vivo role of this protein has not been studied so far mainly due to severe embryonic lethality upon tiar invalidation.
First and foremost, the severe perinatal lethality resulting from the embryonic loss of Taspase1 suggests that inactivation of Taspase1 by genetic or pharmacological means is inadvisable in pregnant females and children in order to avoid potential developmental sequelae.
Our results showed that lentivirus-driven specific knockdown of furin in the mouse placenta led to severe embryonic lethality, and that furin knockdown placenta showed a thinner labyrinth as compared with the control placenta.
In the present study, IL-32α overproduction in Tg mice was associated with severe endotoxin lethality; this was shown to be mediated through the induction of TNFα, because etanercept significantly attenuated the endotoxin shock.
