The prototypical antiangiogenic agent thalidomide has been shown to benefit patients with refractory Crohn's disease, but is fraught with problems, including its terrible legacy of causing severe birth defects during its early clinical use as well as unacceptable rates of neuropathy as an adverse reaction when employed on a long-term basis.
Traditional embankment stabilisation techniques can have severe environmental impacts during construction and frequently leave behind a stark legacy of a bare embankment unsuitable for wildlife and unsightly for local residents.
And that worries scientists, who say aquaculture in China is not just a victim of water pollution but a culprit with a severe environmental legacy.
We hypothesized that this characteristic may help in the differential diagnosis with serpiginous choroiditis, since cases of serpiginous choroiditis may lead to severe atrophic legacy not only in the retina but also in the choroid.
I am severely disabled by chronic pain and severe fatigue, both the legacy of cancer treatment, and depend on wheelchair assistance.
For the psychiatrists who have examined him, Glenn Paul Wright, now 32, is suffering from a severe personality disorder, the legacy of the torment which he suffered as a child.
By the time Mr. Irons visits a Vietnamese hospital for children with severe birth defects — the legacy of Agent Orange — that plastic water bottle in your hand will feel as dangerous as a Molotov cocktail.
As reports on Iraq reach Congress this month, it's worth considering that blow-back from an oil-rich country at the heart of the battle for the Middle East could be even more severe than the violent legacy of funding Islam to fight communism in Kabul.
Wireless multi-hop networks often experience severe performance degradations when legacy routing algorithms are employed, because they are not optimized to take advantage of the peculiarities of wireless links.
Acid mine drainage (AMD) resulting from extensive coal mining throughout Appalachia since the 1800s has caused a legacy of severe acid and dissolved metal loads to thousands of stream miles, which has critically impacted aquatic life and ecological attributes.
