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This means that GMMs and hidden Markov models cannot handle severe late reverberations precisely.
However, the currently used therapy is associated with severe late side effects.
Epicormic resprouts were not observed at the more severe late burns.
External fixators designed specifically for severe, late postburn contractures of hand and wrist have been used in five patients between 1993 and 1997 with follow up for an average of 30.2 months.
Severe late radiation-induced toxicities were recorded.
We did not find severe late complication.
Severe late toxicity was observed in 6 pts (18%).
Severe late toxicity was observed 6 patients (18%).
No other severe late complications were encountered during follow-up.
Hyperfractionation is simply the tool to enable dose escalation without an increase of severe late toxicity.
Severe late effects were uncommon, despite the combination of oxaliplatin and radiotherapy.
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