Sentence examples for severe involvement of from inspiring English sources

FUS-atypical FTLD-U (based on only two cases with MRI) was associated with largely symmetric atrophy, most marked in the frontal lobes but also involving the temporal lobes and with severe involvement of caudate.

Lesions were graded on a scale from 0 to 4: 0 = normal; 1 = mild, involvement of less than 25% of the cortex; 2 = moderate, involvement of 25% to 50% of the cortex; 3 = severe, involvement of 50 to 75% of the cortex; 4 = extensive damage involving more than 75% of the cortex.

However, in notable contrast to MSA, in which the putamen has a gradient of pathology most severely affecting the posterior and dorsal aspects of this nucleus with less severe involvement of the caudate, there was a uniform distribution of pathology in all regions of both nuclei in this case [ 1, 58].

In cases like those involving the internal condyle of the knee, where there is osteonecrosis with severe involvement of the subchondral bone, autologous osteochondral grafts are performed.

Signs of severe involvement of the liver, kidneys, and central nervous system soon follow, including a decrease in urinary output and a lowering of blood sugar.

Patient 366 had a very pronounced systemic amyloidosis with severe involvement of many parts of the body including both parenchymatous and non-parenchymatous organs.

Semiquantitative analysis of infiltrate was also performed, and inflammatory infiltrate was classified as follows: mild (involvement > 25% of the tissue), moderate (25%50%% of the tissue), or severe (involvement > 50% of the tissue).

The use of a dilator for vaginal stricture in the absence of symptoms as an indicator of severe involvement was controversial.

Often it is only later in the course of the condition that one can clinically determine areas of severe involvement.

The VILI scoring system was graded from 0 (normal lung) to 4 (very severe involvement in > 75% of the lung).

Although similar to previous findings in skeletal muscle, 19, 20 the mutational burden appeared higher in the brain, correlating with its more severe involvement in this type of POLG disease.