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Voids and cracks may occur in the interconnects, causing a severe increase in the total resistance and even open circuits.
Any severe increase in the deformity during the excursion of the iliac apophysis was considered to be indicative of a nutritional deficiency.
Similarly to what was observed in HeLa cells, SRSF1 depletion in HT1080 resulted in a significant, albeit less severe, increase in the time these cells spent in mitosis.
One of the possible mechanisms of prevention may partially be related to suppression of severe increase in the levels of pro-inflammatory cytokines which was observed in STZ diabetic rats.
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It has been shown that abnormal and severe increases in the intestinal permeability are associated with the onset of MODS in critically ill patients [ 38].
Further, contact cooling helps further prevent severe increases in the surface temperature, 6 to allow delivery of NIR safely and efficiently to the deeper tissues.
We found that there were no differences in toxicity between unmodified 0N4R or 2N4R Tau and those containing the R406W point mutant when expressed from the same insertion site, in contrast to the severe increase in toxicity in the eye reported previously for the R406W mutation (Wittmann et al., 2001; Jackson et al., 2002; Nishimura et al., 2004) (Fig. 3A, upper panels).
Because of the described severe increase in esophagitis in the third group and the expected complications such as severe dysphagia and odynophagia, ulceration or occlusion, we did not realize the next step of dose escalation.
Moreover, while deficiency in TDP1 did not affect ETP-sensitivity of the Jel1 mre11Δ derivative expressing MRE11, it did cause a modest increase in ETP-sensitivity of the Jel1 mre11Δ derivative expressing mre11-H59A, and a more severe increase in sensitivity of the derivative expressing mre11-H125N (Fig. 4, lower).
MTA 4 represents severe increase in width of the choroid fissure and temporal horn, and a severly decreased hippocampal height.
Due to the severe increase in vascular permeability associated with HPS, disease progresses rapidly (within hours) to respiratory failure, shock, ARDS, coagulopathy, and arrhythmias [ 104, 105].
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