Altogether, WDR73 mutations cause Galloway-Mowat syndrome in a particular subset of individuals presenting with late-onset nephrotic syndrome, postnatal microcephaly, severe intellectual disability, and homogenous brain MRI features.
We found that the effects of corticosteroids on mean time to onset of pain relief were homogenous in severe, exudative, or bacterial pathogen positive sore throat alone.
This homogenous modification of severe CAP antibiotic management in our ICU gives us the further opportunity to assess the influence of a fluoroquinolone with enhanced activity against S.pneumoniae.
These results were novel, since no similar observations in a homogenous group of severe asthmatics over 60 years of age had ever been performed.
Furthermore, the population was relatively homogenous since only patients with severe blunt trauma were included.
There have been some reports that support the notion that melancholic depression is often identified with severe depression, an assumption coming from the homogenous or unitarian position [ 16].
The main reason for this discrepancy might be the difference between the homogenous group of patients with severe sepsis or septic shock presented here and the more heterogeneous cohorts of ICU patients enrolled in the other studies.
Due to differences in definitions of outcomes assessed in respective studies, the composite endpoint in this analysis encompassed either overall, severe or nocturnal hypoglycemic events; nevertheless, only homogenous results were allowed for statistical accumulation.
Recent prospective data of brain temperature and outcome in a relatively homogenous population of patients with severe traumatic brain injury (TBI) show that outcome is worse at temperature extremes (high and low) [ 2].
Strengths of the study include a well-conducted multicenter trial, inclusion of a homogenous group of patients with severe ARDS, use of lung protective ventilation in both arms, and use of standard ventilator weaning protocols.
The sample was relatively homogenous, with all subjects having moderate to severe COPD, the majority being ex-smokers with a significant smoking history.
