Sentence examples for severe guidance from inspiring English sources

Thus, in unc-14 and unc-51 mutants, the Netrin receptor accumulates in neural cell bodies rather than at axonal termini, causing severe guidance defects in the DD/DV neurons [23].

We found that Ryk knockdown caused severe guidance errors in about a third of axons (n = 7 out of 23) analyzed [ Fig. 4(A,B)].

In the corpus callosum CaMKII inhibition reduced the outgrowth rate of postcrossing (but not precrossing) axons and caused severe guidance errors which resulted from reduced CaMKII-dependent repulsion downstream of Wnt/calcium.

We found that D-type neurons showed severe axon guidance defects in lin-17 mutant animals (Fig. 2A C).

Axon projections from Tsc1 mutant photoreceptors in the brains of third instar larvae and pupae showed severe axon guidance abnormalities (Figure 5B, F, F', quantified in Table 1).

Tsc1 mosaic pupae show severe axon guidance abnormalities and Tsc1 mutant animals do not survive to the pupal stage; in contrast, animals bearing both a Tsc1 mutation and a hypomorphic Tor allele survived to pupal stages and showed only modest axon guidance abnormalities in larval and pupal brains (Figure 6G, H, Table 1).

We show that homozygous Dicer mutant mice exhibit severe axon guidance defects in the visual system, including an increased ipsilateral projection, axons extending ectopically outside the region of the optic chiasm, the formation of a secondary optic tract, and aberrant growth of RGC axons into the contralateral optic nerve and eye.

While the growth defects of Tsc1 mosaics were rescued by rapamycin treatment, photoreceptors from these animals still showed severe axon guidance abnormalities in the third instar larval brain, with an irregular and disrupted lamina plexus, as well as disorganized projections to the medulla (Figure 7E, Table 1).

According to the European Medicines Agency EMEAA) classification, none of these AEs are rated as "serious" or "severe" (regulatory guidance CPMP/ICH/377/95).

In the past, when an accident occurred, operators in nuclear power plants (NPP) followed emergency operating procedures (EOPs) or severe accident management guidance (SAMG).

We do not routinely correct coagulopathy, even if severe, when ultrasound guidance is used and the purpose of this retrospective study was to evaluate the safety of this practice.