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We identified 645 genes which had a 2-fold change in expression between the severe and less severe groups with FDR at 5% and Bonferroni multiple test correction.
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16 The fastest decline was in the group with moderate obstruction with FEV1 50% 80% predicted and lower in the severe group with FEV1 < 30% predicted.
In this study, the number of microaneurysms in the moderate group were 14.5 ± 2.3; while was 27.5 ± 5.7 in the severe group, with significant difference (P < 0.05).
«Others" seemed to be the less severe group with total and LDL-cholesterol levels significantly lower and presence of xanthomas or evidence of CHD rarer.
The patients in the RAVE study are likely to have a greater rate of progression to end points as they will be a more severe group with ARVD.
In particular, the two groups of patients with more severe pain were older than the two groups with milder pain and there were fewer females in the more severe group with longer time to depression diagnosis.
HRQoL of the severe group with CH appeared to be significantly worse (p < 0.007) than that of the norm population on motor and cognitive functioning; F 1,502) = 26.61 and F 1,502) = 36.36 respectively.
It increased remarkably in the moderate and severe groups, compared with the two control groups and the mild arsenicosis group (p < 0.05 or p < 0.01; Table 1).
A separate comparison for severe and very severe groups of patients with COPD was impossible since the original CCQ article [ 3] presents data in these patients, grouped according to the classification criteria available in January 2003.
When Kaplan Meier analysis was repeated for those patients of the most severe group (those with SOFA ≥ 8), no thresholds associated with mortality were identified for individual immunoglobulins (Fig. 2).
While pain and QOL improved across all three groups at the end of 10 years, the severe group remained with significantly more pain and decreased QOL than in the milder groups.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com