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However, as bone replaced chondrocytic areas throughout the pathology, notochordal tissue did not calcify until the deformity developed into severe fusion.
They generated mutant mice lacking the intron sequences of Hes7 gene alleles, and found that the oscillatory expression of Hes7 is abolished in these mice, resulting in severe fusion of somites.
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We observed an increased transcription of runx2 in the chordocytes of incomplete fusions and in the chordoblasts and chordocytes in more severe fusions.
Sox9 was also transcribed at the vertebral growth zones of the endplates and the signal was extending axial in severe fusions.
The shrinkage control effect vanishes at the second transition, when severe particle fusion is observed in the sample because of too high an additive concentration.
Prenatal sonographic follow-up showed diffuse severe vertebral fusions.
RAMI (Reliability, Availability, Maintainability and Inspectability) is one of the most severe challenges of Fusion Technologies, and it is probably the engineering branch where the fusion community is the least competent.
Failures during hydrotest have been analyzed for a new crude oil pipeline, indicating that the main cause of failures is severe lack of fusion defects formed by inadequate welding heat input in electric resistance welded (ERW) pipe welds.
After anterior release and fusion, severe and rigid curves can be instrumented combined, anteriorly and posteriorly, with safe and effective tridimensional correction.
Fourthly, the average duration of disease in patients with AS was more than 11 years, and some patients had severe contracture or fusion of the spinal joints.
In AS patients with long duration, severe contracture or fusion of spinal and peripheral joints was frequently present, and gentle range-of-motion was not effective in improving the mobility of joints.
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