Sentence examples for severe functional changes from inspiring English sources

We chose to examine DNA variants in cytochrome P450 genes that cause or are suspected to cause severe functional changes in the targeted proteins.

Since CC is supposed to be a collection of conserved features in the cell, this tells us that mammals and non-mammals have undergone severe functional changes in the cell.

Indeed, with the decreasing glomerular filtration rate, the vasculature is progressively exposed to a burden of pathogenetic conditions responsible for severe functional changes in the endothelium, such as reactive oxygen species (ROS), assymetrical dymethylarginine (ADMA), homocysteine or glycosylated end products [ 8- 11].

Briefly, Class I included pathogenic variants previously known to cause RP, and Class II variants were expected to cause severe damage to protein structure via frameshift, nonsense, and missense variants, which were likely to cause severe functional change via Polyphen 2 [ 40], SIFT [ 41], and MutPred [ 42].

An important observation of these studies is that dasatinib treatment induced severe morphological and functional changes in the sensitive MDA-MB-231 cells.

Exposure of the lung to high dose levels of radionuclides produces a spectrum of progressively more severe functional and morphological changes, ranging from radiation pneumonitis and fibrosis to lung tumors.

Strict BP control is necessary to prevent severe functional and structural vascular changes in the course of hypertensive disease.

The lesions are possibly more severe in winter, reflecting functional changes associated with the micro- and macroangiopathy.

It appears reasonable that strict BP control associated with reducing AS should be obtained to prevent severe functional and structural vascular changes during the hypertensive disease's course.

We used antisense morpholino technology to generate zebrafish embryos with dominant-negative transcripts of col6a1 that result in severe morphologic, structural and functional changes.

Recent research on the impact of problem behavior on caregivers and vice versa shows that these specific aspects of the dementia, more so than cognitive and functional changes, have severe consequences for patients and their family members [ 9].