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These exclusion criteria combined with the rarity of cholestasis in severe flares of chronic hepatitis B likely account for the high specificity of our algorithm despite case reports of jaundice in flares of chronic infection.
Patients with severe flares had the highest costs.
Patients with pancolitis appear to be predisposed to severe flares.
Because flares, especially severe flares, represent a significant economic burden in SLE patients, SLE treatment that prevents or reduces severe flares may generate significant cost savings.
Patients who experienced severe flares (25% of the sample during followup) also incurred the highest annual total costs compared to patients with less severe flares.
Annual total costs for patients with severe flares were $49,754.
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To capture increasing severities of flare, six HS were developed including three separate HS for severe flare (severe generalised flare, severe renal flare, severe CNS flare).
The standard treatment for four decades has been the use of topical steroids -- or oral ones for severe flare-ups -- which have some risks if used chronically.
So Rhône-Poulenc, which became Aventis after a merger, continued to make a limited supply that was rationed to treat only infantile spasms or severe flare-ups of multiple sclerosis.
The effectiveness of multiple sclerosis drugs is often judged by how much they reduce the frequency of relapses, which are severe flare-ups of symptoms, compared to a placebo in clinical trials.
Patient 6 had a slow disease progression prior to erlotinib scanning; she stopped erlotinib therapy after her first scan but developed a severe flare of her disease within 1 week.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com