The cause of their wrath is Orfeo and his renunciation of women; he will not escape their heavenly anger, and the longer he evades them the more severe his fate will be.
Together, these data suggested that Nde1 Lis1 double deficiency resulted in a severe cell-fate defect in the cortical neural progenitors, leading to precocious overproduction of earliest-born PP and C R neurons in the mutant cortex at the expense of progenitor cells.
Loss-of-function mutations of the par genes abolish the tightly controlled polar distribution of maternally expressed regulatory proteins, resulting in severe defects in cell fate specification (Schneider & Bowerman 2003).
By analyzing and comparing the phenotypes of an allelic series of Nde1 Lis1 single and double mutations, our study showed that the most severe alteration of cell fate correlates tightly with the cell morphology and cytoarchitecture defects of radial glial neuroepithelial progenitors (Table 1).
A different fate awaited the severe, bony Robespierre, the trio's leader.
It's easy to admire the comebacks of those whom fate has dealt severe blows, like Lance Armstrong's recovery from cancer to win the Tour de France.
Are you having trouble concentrating on things, such as reading the newspaper or watching TV?" She pelted the questions at me one after the other before pronouncing my fate: "You have severe anxiety and moderate depression".
He is very happy despite a headache, sore throat, bleared eyesight, severe nasal congestion, and the tragic fate of lobsters.
Lef1 represents another main effector of this pathway in HF morphogenesis; indeed, Lef1- null mice lack hair coat, and transgenic mice overexpressing inactive forms of Lef1 present severe alteration of differentiation and HF cell fate.
Different inducer concentrations could result in different fates of the cells, for example severe death, modulated death, or slow growth.
