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This threshold value increases with the severity of COPD, because the differences between treatments in the probabilities of developing a (severe) exacerbation decrease as COPD severity increases.
61% of GPs declared disease severity to be an important factor in treating patients with a severe exacerbation.
In addition, the severity of an exacerbation does not always reflect underlying asthma severity (i.e. women with mild asthma can have a severe exacerbation).
The primary end point is time to first moderate or severe exacerbation following randomized treatment over 52 weeks.
Co-primary endpoints were 1-year severe exacerbation rates, risk-domain asthma control, and overall asthma control; secondary endpoints included therapy change.
The rate of M. pneumoniae was highest (40%) in the severe exacerbation group.
Moreover, approximately one-third of severe exacerbation episodes remain without identified cause [22, 28 32].
All studies included COPD patients (mean baseline FEV1 = 808 ± 110 ml), experiencing severe exacerbation requiring ventilatory support.
In those with a severe exacerbation, antibiotics improve outcomes.
Most individuals can develop severe exacerbation from a number of triggering agents.
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Also the costs per disease severity state and per severe or non-severe exacerbation were mentioned to be equal across treatment groups.
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CEO of Professional Science Editing for Scientists @ prosciediting.com