Exact(3)
Although some degree of acneiform rash occurs in most patients, severe eruptions resulting in significant pain, pruritus, or infectious sequelae are rare.
The effects of such severe eruptions can be seen over a large territory, even at global scale and environmental changes arising as their result are observed not only for a single growing season but also for a few years after the event (Scuderi, 1990).
We conclude that imatinib acts as a dose-dependent inducer of cutaneous adverse reactions with mainly mild reactivity to low or intermediate doses (200 600 mg day−1) but severe eruptions to high doses (600 1000 mg day−1) of the drug.
Similar(57)
As large as that seems, volcanoes release 200 billion tons of carbon dioxide per year in a normal year when a severe eruption does not occur.With this science and these numbers in mind, any human or corporate effort to reduce carbon dioxide is so miniscule as to be meaningless.
Drug‐induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/ DRESS) and Stevens Johnson syndrome (SJS /toxic epidermal necrolysis (TEN) represent contrasting poles of severe drug eruptions, and sequential reactivations of several herpesviruses have exclusively been demonstrated in the former.
Longitudinal studies could help determine whether an increase in viral loads occurs in association with the development of severe drug eruptions or whether individuals with increased viral loads are at greater risk of developing severe drug eruptions.
Thus, these previous studies are not sufficient to explain the difference in clinical manifestations and long‐term outcomes associated with these severe drug eruptions, some of which occurred after a disease‐free interval of several months to years 12.
Severe mucosal eruptions and intestinal signs were not detected.
Patients with severe drug eruptions who visited our hospital between 1999 and 2012 were enrolled.
191 Severe dermatologic eruptions including toxic epidermolysis, acute generalized exanthematous pustulosis, and Steven's Johnson syndrome have also been associated with terbinafine use.
This event stimulated many investigators to systematically search for herpesvirus reactivation during the course of other severe drug eruptions, SJS/TEN.
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