Although some degree of acneiform rash occurs in most patients, severe eruptions resulting in significant pain, pruritus, or infectious sequelae are rare.
We conclude that imatinib acts as a dose-dependent inducer of cutaneous adverse reactions with mainly mild reactivity to low or intermediate doses (200 600 mg day−1) but severe eruptions to high doses (600 1000 mg day−1) of the drug.
The effects of such severe eruptions can be seen over a large territory, even at global scale and environmental changes arising as their result are observed not only for a single growing season but also for a few years after the event (Scuderi, 1990).
Beyond that, Being raised in New York I have pretty limited knowledge on how severe an eruption can be, my sources being "Volcano," "Dante's Peak," and that paper-maiche, baking soda and vinegar experiment from third grade.
The other two patients received 50 Gy of radiation therapy due to severe drug eruption or ischaemic enteritis.
Eighteen subjects withdrew prematurely due to a rash AE, including one subject, receiving allopurinol, who had a severe desquamating eruption requiring parenteral corticosteroid therapy.
Cowpox with a severe, generalized eruption was diagnosed in an atopic 4-year-old girl by electron microscopy, virus isolation, polymerase chain reaction, and immunoglobulin (Ig) M and low-avidity IgG antibodies.
There was one case of severe skin eruption 18 days posttreatment (DP), one case of chickenpox 12 days posttreatment (AL), 1 case of abscess 11 days posttreatment (DP), 1 case of leukocytosis 2 weeks posttreatment (AL), and 3 cases of asthenia (2 AL and 1 AA).
Drug‐induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/ DRESS) and Stevens Johnson syndrome (SJS /toxic epidermal necrolysis (TEN) represent contrasting poles of severe drug eruptions, and sequential reactivations of several herpesviruses have exclusively been demonstrated in the former.
Thus, these previous studies are not sufficient to explain the difference in clinical manifestations and long‐term outcomes associated with these severe drug eruptions, some of which occurred after a disease‐free interval of several months to years 12.
