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Normal lactate levels postoperativelly were detected in 127 (46,86%) patients, moderate hyperlactatemia in - 105 (38,75%), and severe elevation of lactates in - 39 (14,39%) patients.
Expect severe elevation gains and losses, and plenty of mud and water on the trail during the winter and spring season.
Moderate elevation (>3×ULN) and severe elevation (>5×ULN) were recorded in none of the cases.
Moderate elevation of liver enzymes (>3×ULN) was observed in only 3 cases and severe elevation (>5×ULN) in none.
Moreover, an increase of activity before immobilization can lead to the production of heat in the muscle and severe elevation of body temperature [ 47].
Malignant hypertension was defined as severe elevation of mean arterial pressure in combination with grade III to IV hypertensive retinopathy, according to the Keith-Wagener and Barker classification.
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Two relatively new drugs useful in the management of severe elevations of low-density lipoprotein cholesterol have been approved under a requirement for a REMS.
This disease is characterized by severe elevations of low-density lipoprotein cholesterol (LDL-c), with the possibility of deposits in different tissues.
This mouse model, designated "human only" (HO), exhibits severe elevations in both plasma and tissue levels of Hcy, methionine, S-adenosylmethionine, and S-adenosylhomocysteine and a concomitant decrease in plasma and hepatic levels of cysteine.
Creatine kinase levels are elevated in two thirds of cases, usually due to a degree of muscle injury; severe elevations suggestive of rhabdomyolysis (muscle tissue destruction) are rare.
The company later sought FDA approval for a different use -- to treat less severe elevations of blood triglycerides in patients with heart disease or high risk of heart disease -- but the agency rejected the company's application for this use because of a lack of evidence of effectiveness.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com