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The economic sanctions have had a "very severe" effect in Pakistan, says Andrew Hess, director of the Southwest Asia Program at the Fletcher School of Law and Diplomacy.
Both hFXNG130V and hFXNI154F clones showed a significant decrease in the mitochondrial succinate dehydrogenase (SDH) activity with a more severe effect in the hFXNI154F mutants compared to the hFXNG130V mutants with 36% and 54% residual SDH activity, respectively (Fig. 5A).
A previous study also showed a more severe effect in the methylation of the promoter and I3 regions of the Oct-4 gene in the absence of Dnmt3a than Dnmt3b [29].
The D442G acts in dominant negative manner with severe effect in heterozygous state [ 14].
The mutation is supposed to have a severe effect in view of site-directed mutagenesis experiments and phenotypes of some patients.
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Differences between groups were seen in the severity of side effects with a tendency for less severe effects in the NT group (table 4).
If the NBI level is high enough, it will have severe effects in the GNSS receiver signal processing.
Similarly, Collembola (F. candida) showed more severe effects in their reproductive output with increasing ageing duration of Ag NP in spiked sewage sludge [193].
This example brings together considerations about a product that has been on the market for decades, despite outcomes of experiments describing relatively severe effects in cells or animals.
Most congenital abnormalities resulting from mutations in T-box genes have effects in heterozygotes with more severe effects in homozygotes, indicating dosage sensitivity.
Hypoxia induced more severe effects in the gill structures than the harmful alga, whereas the digestive gland was more affected by exposure to M. aeruginosa.
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