As a consequence, the semiconductor detectors close to the interaction region will receive severe doses of fast hadron irradiation and the inner tracker detectors will need to survive fast hadron fluences of up to above 1016 cm−2.
Two weeks after irradiation, cellular colonies significantly dropped at a dosage of 5 or 10 Gy, while almost no colonies were found on the plate treated with 20 Gy, suggesting that irradiating cells with severe doses of γ irradiation induces cell death (Figure 5A and B).
As shown in Figure 9, all three cell lines demonstrated a severe dose-dependent reduction of active p44/42, therefore causing the downregulation of a variety of downstream targets, mainly involved in cell proliferation and survival.
One of the challenges in lung cancer treatment with radiotherapy is the development of severe dose-limiting side effects.
In addition to unpredictable efficacy, MTX is associated with a number of severe, dose-dependent side effects, limiting the tolerable dosage level.
Characteristic cumulative severe dose-related side effects of docetaxel (i.e. fluid retention (peripheral oedema), nail dystrophy and skin reactions) were graded as severe in only 3, 2 and 0% of patients, respectively.
Such designs use dose increments that become progressively smaller with ascending dose cohorts and, so, tend to mitigate against the risk of encountering unexpected severe dose-limiting toxicities that may interrupt treatment.
HSPA6 overexpression did not alter cell viability after HTM cells were exposed to the 'low dose' and 'severe dose' of H2O2.
