Severely disturbed channel function corresponded to severe clinical phenotypes, underlining the important role of facilitated NMDA receptor signaling in epileptogenesis.
Itch is the main symptom, often worse at night and sufficiently severe to disturb sleep.
These toxicities include severe bleeding, disturbed wound healing, gastro-intestinal perforation, hypertension, and fatigue [ 13].
A score of 0 reflects no sign of chronic family difficulties and a score of 6 reflects severe difficulties/very disturbed family environment (Table 1).
The total burden of difficulties was scored on an interval scale from 0 to 6, with 0 indicating no sign of chronic family difficulties and a score of 6 indicating severe difficulties/very disturbed family environment (Table 1).
HGPS is a severe disorder that disturbs several organ systems leading to hair loss, decreased adipose tissue, increased bone fractures, short stature, vascular stiffness, and severe atherosclerosis.
Though plastic and polythene are durable and strong with wide applications, they seem to be non-degradable leading to severe pollution issues by disturbing the whole ecosystem.
Regardless of disclosure status, the children's drawings and conversations suggested severe emotional distress, disturbed self-image, and social isolation.
The angelshark is generally unaggressive towards humans, though it can deliver a severe bite if disturbed.
Qualitatively, the pregnant women in our study more frequently reported pain severe enough to disturb normal daily activity, which may well help explain why pregnant women were often less active than non-pregnant women.
