Sentence examples for severe differentiation from inspiring English sources

Moreover, even the ESL G11 cell line with the most severe differentiation morphology failed to generate obvious EB by day five, suggesting severely compromised differentiation capability (Figure 5B h).

Unlike other PRC2-deficient embryonic stem cells (ESCs), however, Jarid2-deficient ESCs show a severe differentiation block, altered colony morphology, and distinctive patterns of deregulated gene expression.

Two independent studies suggested Dicer dependent pericentromeric RNA processing in mammals, which, when impaired, leads to the accumulation of satellite transcripts of various sizes and severe differentiation defects and cell death [ 99, 100].

Ptdsr-deficient mice are dying at birth and display severe differentiation defects in many tissues such as brain, eyes, lung, kidney, liver and intestine at different stages of embryogenesis [ 54, 62, 63].

In the absence of LIF, ER stress inducers thapsigargin, tunicamycin and ionomycin lead to more severe differentiation and higher expression of ER stress-related genes and VEGFA, while tauroursodeoxycholic acid, salubrinal and BHA, the ER stress inhibitors, blocked the expression of ER stress-related genes and VEGFA caused by the removal of LIF, and thus prevented cell differentiation.

The bacterial community between plots of the same N or P input rate was much more dissimilar with the higher input level, indicating more severe niche differentiation in pots with higher N or P input.

On the other hand, the mouse dmrt2 null mutants have severe somite differentiation defects but nothing was known regarding a possible role of Dmrt2 in regulating symmetric somite formation and establishing the LR asymmetry pathway [24].

Expression of HAT proteins was successfully abolished, and these cells showed severe myotube differentiation defects with low myosin heavy chain staining and 90% decrease of myotube fusions.

In support of this hypothesis, a keratinocyte-specific Ikkα disruption results in a less severe epidermal differentiation defect with altered skin barrier function than the total Ikkα knockout (Gareus et al, 2007).

For example, we found that Lsd1 deletion with VavCre or Mx1Cre resulted in severe HSC differentiation and self-renewal defects resulting in complete loss of lineage-negative c-Kit+ myeloid progenitor cells, whereas Sprüssel et al. (2012) did not observe a defect in LT-HSCs.

c587-mediated wnt2 and wnt4 double knockdown results in more severe germ cell differentiation defects than wnt2 or wnt4 single knockdown.