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Children with microcephaly are born with abnormally small heads and suffer severe developmental disorders.
Although severe developmental disorders do not predominate in TS, the risk of selective deficits in certain cognitive domains is substantially increased.
This state is called aneuploidy, and can also cause embryos to be miscarried, or to be born with severe developmental disorders.
Mutations in other MRC-related genes may well underlie severe developmental disorders hallmarked by a respiratory phenotype and caused by activation of mitochondrial apoptosis.
As a result, children with severe developmental disorders, such as autism or intellectual disabilities, were most probably excluded because they have already accessed the system at an earlier age.
Neural tube defects are severe developmental disorders of the brain or spinal cord and one of the most common with a frequency of about 1 per 1000 births in humans (Mitchell, 2005).
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Owen Suskind is a young man in the US who, at three years old, had succumbed almost overnight to a severe developmental disorder, retreating into silence or gibberish.
Florida senator Marco Rubio has said women infected with the Zika virus should not be allowed to have abortions, even if their babies have microcephaly, the severe developmental disorder than can result from infection with the disease.
But even if parents who learn a child will have a severe developmental disorder decide against an abortion, they and their doctors might be better prepared for a baby's needs.
Autism is a severe developmental disorder of childhood.
Autism Spectrum Disorder (ASD) is a severe developmental disorder defined by social deficits, communication deficits, repetitive behaviors and fixated interests that appear in early childhood [ 1, 2].
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