Sentence examples for severe developmental abnormalities from inspiring English sources

DOI: http://dx.doi.org/10.7554/eLife.01160.012 Consistent with its widespread expression during embryogenesis, we observed that loss of Megf8 leads to severe developmental abnormalities in several organ systems.

The sulfation patterns of HS chains are tissue specific and mutations in enzymes that are involved in HS chain sulfation lead to severe developmental abnormalities [36], [38], [43].

Moreover, mammalian SIRT1 knockout is typically embryonic lethal, with surviving mice displaying severe developmental abnormalities including exencephaly, sterility and heart/retinal defects [5], [6], [8].

Mice lacking both APP and APLP proteins (triple APP/APLP KO-mice) show early postnatal mortality with severe developmental abnormalities [41], [42], [43], [44], [45].

Injection of pacsin3 AUG antisense morpholino oligonucleotide (MO) (Table S2) into wild-type one- or two-cell embryos causes severe developmental abnormalities, in a dose-dependent manner (Figure 4A E and S4).

Defects in this process result in severe developmental abnormalities.

Disruption of the Pgap1 (post-GPI attachment to proteins 1) gene by KO and ENU-generated mutation results in severe developmental facial abnormalities with incomplete penetrance in KOs and strain dependence with ENU mutations.

Deletion of the miR-106b-25 cluster in mice does not result in any obvious phenotype but loss of both miR-106b-25/miR-17-92 clustembryonicts in embryonic death associated with severe cardiac developmental abnormalities, consisting of defective ventricular and atrial septation and thinner ventricles.

In mice, experimental reduction or mutations of miRNAs in the inner ear leads to severe developmental and structural abnormalities.

Most methods used to arrest the progress of transgene silencing include the use of cytidine analogs or viral methylation inhibitors, but these substances can cause severe growth and developmental abnormalities [ 68].

This is particularly so within the first three years of birth to prevent severe and irreversible developmental abnormalities of the central auditory system, impairment in language acquisition and speech development in early life, poor educational performance in childhood and adolescence, and poor occupational performance in adulthood [ 3, 6- 9].