Sentence examples for severe destabilization from inspiring English sources

Mutations mapping to the β-domain of the protein predisposed to severe destabilization.

In Y133H, the induced conformational changes led to a severe destabilization and almost complete loss-of-function with a residual catalytic activity of 3.5%.

The location of these residues at the juncture of these two protein regions would rationalize the more severe destabilization observed when these residues are substituted to generate R63S (Tm ∼43 °C) and W11F (Tm ∼25 °C), with melting temperatures reflecting destabilization of both MftR regions D1 and D2.

This severe phenotype reflects a destabilization of KT MT interactions, as demonstrated by reduced cold stability of KT fibres.

On Tuesday morning, the White House released the latest in a long line of reports documenting the increasingly severe threats arising from global climate destabilization (or climate change).

Upon further aging of these mice, or in the homozygous mouse where the disease is more severe, it is likely that microtubule destabilization results.

In addition, we induced DRM destabilization by several alternative mechanisms.

"If in fact we see the disruptions and the destabilization continuing so severely that it impedes elections on May 25, we will not have a choice but to move forward with additional, more severe sanctions".

Several other factors contributed to the destabilization of Poland.

It's been hard for me to see the destabilization of Damascus.

Accordingly, we propose that the truncation of the COQ9 protein in the Coq9 R239X mouse model would have two consequences: (i) severe and moderate reduction of COQ7 and COQ5 levels, respectively, and (ii) destabilization of the multiprotein complex, decreasing therefore the levels of the other COQ proteins.