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Degron tagging of ERG20 was therefore paired with a sterol responsive promoter to ensure sufficient metabolic flux to essential downstream sterols despite the severe destabilisation effect of degron tagging.
The Ala353Val mutation however, did lead to severe destabilisation of TERC, a reduction in telomerase activity, and a continuous shortening of telomeres with increasing numbers of cell divisions in culture.
These points are from residues which make long-range contacts in the SAP native state (L17A, R20A and L35A) and deletion of these contacts results in severe destabilisation of SAP domain.
Similar(57)
Pakistan has suffered terrible destabilisation.
The marshy ground has led to several buildings sinking, causing structural destabilisation, along with a picturesque leaning.
Solidarity, not destabilisation.
Increasing temperatures, one of the longest and most severe droughts in 50 years and the steady drying up of farmland as rainfall diminishes have been identified as factors in the political destabilisation of Syria.
It began a process of destabilisation.
These shifts increase the effect of destabilisation.
Inevitably, there is a risk of unrest, destabilisation and violence.
First, the destabilisation of eastern Ukraine is unacceptable.
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CEO of Professional Science Editing for Scientists @ prosciediting.com