Sentence examples for severe defects that from inspiring English sources

As had been explained to me by several distraught obstetricians, he had severe defects that were incompatible with life, the worst being anencephaly, an absence of a portion of the brain and skull.

We employed zebrafish to investigate the possible functional role of Numb and Numblike during hematopoiesis, as this system allows a detailed analysis even in embryos with severe defects that would be lethal in other organisms.

One of the most severe defects that can be prevented is neural tube defects (NTDs).

Deleting a locus postnatally, or in a particular tissue, allows severe defects that are otherwise not survivable to be overcome.

Tracheal expression of Rac1-CA in a wild-type background produced severe defects that prevented assessment of interactions with the Ptp4E phenotypeenotyphenotype

For the severe defects that cause complete loss of functional mtDNA, heteroallelic strains can be easily constructed, and they provide valuable insights into the effects of these alleles, including dominance/recessiveness relationships that can be crucial for understanding the effects of corresponding human variants.

We then performed cdc-45 and mcm-7 double RNAi and observed the milder decondensation defect that is typical of mcm-7 RNAi, rather than the severe defect that is normally associated with cdc-45 inactivation.

On Monday, doctors removed Beatriz's fetus — which had a severe defect that prevented the brain from developing — through an incision in her abdomen.

They found that Apoe −/− and APOE4 mice, but not APOE2 or APOE3 mice, had severe BBB defects that were caused by defective regulation of the levels of cyclophilin A (CypA).

However, severe morphogenetic defects that occur early in embryogenesis in these embryos precluded assigning a direct role for Fn1 in cardiovascular development.

In a previous study examining lysine production from starch by C. glutamicum cells expressing PgsA-anchored α-amylase, cultivation at 40°C resulted in severe growth defects that were accompanied by dramatic decreases in lysine production and starch consumption compared to those observed at 30, 34, and 37°C (Tateno et al. 2007a).