Severe convulsions, paralysis, and cardiac irregularities precede death.
The disease is fairly mild but can cause frequent hypoglycemia (low blood sugar), producing severe convulsions that may lead to mental retardation.
Seven days later, when homozygotes showed most severe convulsions, NMJs were in addition often fragmented.
Therefore, we took advantage of the DLS/LeJ mouse line which carries the recessive dilute lethal Myo5ad-l allele (homozygous leading to light fur colour, severe convulsions and death within three weeks after birth).
Later stages include vomiting, severe confusion, convulsions or even coma.
The CHWs were trained and expected to identify the following signs of severe illness: convulsion, hotness or coldness, failure to breastfeed, rapid breathing in a calm baby, grunting, lack of movement on stimulation, yellowing, in-drawing of chest, umbilical cord with pus, and skin papules with pus, with special attention to babies who were born preterm and/or of low birth weight.
The incidence of convulsions, in particular febrile convulsions, has recently received much attention after an increased incidence of severe febrile convulsions in young children led to the suspension of the 2010 seasonal influenza vaccination programme in Western Australia.
Severity criteria included decreased consciousness (coma or severe prostration), convulsions, respiratory distress or acidotic breathing, shock, severe symptomatic anemia, hypoglycemia, hemoglobinuria, or severe jaundice.
Severity criteria included decreased consciousness (coma or severe prostration), convulsions, respiratory distress or acidotic breathing, shock, severe symptomatic anemia (<5 g/dL), hypoglycemia (<3 mmoL/L), hemoglobinuria, severe jaundice, or a convincing history of anuria or oliguria in adult patients.
