Sentence examples for severe compound from inspiring English sources

Interestingly, protein loss in each case was more severe in Patient 4, perhaps reflecting the more severe compound heterozygous frameshift and splice-site mutations.

This may reflect the more severe compound heterozygous frameshift and splice-defect nature of the mutations that make the product vulnerable to nonsense-mediated mRNA decay and subsequently affect the steady-state levels of LRPPRC protein.

The diagnosis of SCD was established by either DNA sequencing or high performance liquid chromatography/clinical history and was further sub-typed as homozygous SS, combination of Hb S with β-thalassemia-zero (HbSβ; generally severe) or compound heterozygous SCD (generally clinically milder; including HbS with HbC (HbSC) or β-thalassemia-plus (Sβ+) [ 22, 23].

As the procedure requires angiograms to be performed in severe and/or compound oblique views in order to optionally evaluate the landing zones, it is crucial to use a state-of-the-art fluoroscopy machine or dedicated new-generation C-arm.

MARKET OVERVIEW A severe recession compounded by a national debt crisis has had a profound impact on Greece's real estate market.

In addition, clinically more severe, recessively inherited, compound heterozygous mutations were demonstrated.

Alleles of each gene that produce mild phenotypes or no phenotype in isolation can cause severe disease in compound heterozygous mice and humans (36, 136).

Motor nerve conduction studies yielded a mild increase in distal motor latencies of median nerves with severe reduction of compound muscle action potential, more on the right, whereas ulnar nerves were less affected.

Severe water shortages compound the misery of millions in war-torn Syria - says UNICEF AMMAN, Jordan, 25 August 2015- Amid the unremitting brutality of the war in Syria and a scorching summer heat wave, there is increasing evidence that parties to the conflict are using water to achieve military and political gains.

The analysis shows that the retarding effect of countercurrent water transport on organic extraction can be severe for organic compounds with low salting-out coefficients (e.g. phenolic compounds) or for salts with strong influence on water activity (e.g. AlCl3).

An accelerating depreciation of the assignats compounded severe shortages of grain and flour in 1793.